VIDEO

Latest Research on GLP-1 Medications and Long-Term Weight Loss

Reviewed by Tama Porter, M.D.
February 06, 2025

GLP-1 medications, such as semaglutide and liraglutide, have been gaining attention for their potential to combat obesity. But many people wonder if they can provide a sustainable solution. This video explores the latest research findings.

Originally developed to help people manage type 2 diabetes and improve blood glucose control, GLP-1 medications have an added benefit: they help regulate appetite and promote weight loss.

GLP-1, or glucagon-like peptide-1, is a hormone that helps regulate appetite and blood sugar. Medications that mimic GLP-1 have been shown to help people lose significant amounts of weight by reducing hunger and increasing feelings of fullness.

Recent studies published in The New England Journal of Medicine and The Lancet reveal remarkable findings. Participants taking GLP-1 medications, combined with lifestyle changes, lost an average of 15-20% of their body weight over a year. And many maintained these results for over two years.

These medications are particularly effective for those who are managing weight-related conditions, like type 2 diabetes and heart disease, offering benefits beyond weight loss like improved cholesterol levels, lower blood pressure, and better blood sugar regulation.

But there are caveats. Studies show weight can return if the medication is stopped. There are also potential side effects, including nausea, vomiting, gastrointestinal upset, and in rare cases, more severe complications like pancreatitis. And not everyone responds to these medications the same way.

It’s important to understand that GLP-1 medications are not a magic bullet. They work best when paired with a healthy, low-calorie diet; regular exercise; and ongoing medical supervision.

Weight management is a journey, and GLP-1 medications may be a valuable tool for many. If you’re considering taking one, consult with your healthcare provider to see if it’s right for you.