How Common Are Facial Changes from GLP-1 Medications? Dr. Porter Answers

This article is part of a Q&A series in which a healthcare professional answers your frequently asked questions.

We asked Tama Porter, M.D., an endocrinologist at Rush University Medical Center in Chicago, to share her insight on how one’s face and body might change when taking a GLP-1 medication.

Some people are concerned their face will change as in what the internet is calling “Ozempic-face” — a more wrinkled, sunken, or sagging appearance. How common are facial changes in your experience?

Dr. Porter: So-called Ozempic face is fairly uncommon in my experience and is not an inherent side effect of Ozempic or GLP-1s themselves. It tends to happen with rapid weight loss and in older patients.

Any rapid weight loss will cause facial changes, so it’s recommended to aim for 1 to 2 pounds of weight loss per week. Also, focus on eating a balanced healthy diet with plenty of protein and doing strength training exercises to help you maintain muscle mass. Stay hydrated by drinking plenty of water, and have a skincare routine that works for your skin.

What are some other changes someone taking a GLP-1 may notice in their physical appearance and/or how they feel?

People may notice more loose skin on their face and/or body as they lose weight. They may experience a slowed down gastrointestinal (GI) system that can manifest as constipation.

Many people report more energy associated with weight loss and fewer intrusive thoughts about food — called “food noise.”

Interestingly, women with PCOS (polycystic ovary syndrome) usually report an overall improvement in their well‑being and more regular menstrual periods while on GLP-1 medications.

What changes may be concerning that they may want to talk to their doctor about?

Any prolonged side effects like uncontrollable nausea, abdominal pain, or severe constipation should be discussed with their healthcare provider. If it’s severe, it should be evaluated in an emergency room. Vision loss, especially sudden vision loss, should also be evaluated emergently.