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Effects of GLP-1s Beyond Weight Loss: What Science Says

By Claudia Levi, R.N.
Reviewed by Tama Porter, M.D.
April 15, 2025

GLP-1 medications like semaglutide, tirzepatide, and liraglutide are known for helping with weight loss. But scientists have found they may have other health benefits, too.

Here, we explore recent findings that show these drugs have promise for improving heart disease, sleep apnea, brain health, and more.

Type 2 Diabetes Management

GLP-1 medications were first created to help people with type 2 diabetes. They improve how the body handles blood sugar by increasing insulin and slowing digestion. This helps keep blood sugar levels steady.

Heart Disease Protection

Studies suggest that GLP-1 drugs may lower the risk of heart attack and stroke. They help reduce inflammation, lower blood pressure, and improve cholesterol levels, which are all important for heart health.

Sleep Apnea

Another recent area of research is how GLP-1 medications may help with obstructive sleep apnea (OSA). Sleep apnea is a condition in which a person stops breathing multiple times during sleep, leading to poor rest and, often, other serious health issues like high blood pressure and heart disease.

Since excess weight is one of the main risk factors for sleep apnea, GLP-1 drugs may help by promoting weight loss, which can reduce fat deposits around the throat that block the airway during sleep.

Fatty Liver Disease Treatment

Metabolic-associated fatty liver disease (MAFLD) is a condition that occurs when fat builds up in the liver. MAFLD can lead to serious liver damage, such as fibrosis (scar tissue), cirrhosis (which can result in liver failure), and liver cancer.

According to research, GLP-1 drugs may help reduce liver fat and improve liver function.

Kidney Health Improvement

For people with diabetes, a higher risk of kidney disease is a major concern. GLP-1 medications may help protect the kidneys by lowering inflammation and improving blood flow, reducing the risk of kidney damage, according to recent studies.

Brain Health and Alzheimer’s Prevention

Researchers are exploring how GLP-1 drugs might protect the brain from diseases like Alzheimer’s disease. Some believe that these drugs may reduce harmful proteins in the brain, lower inflammation, and improve memory.

Polycystic Ovary Syndrome (PCOS) Treatment

PCOS affects many women and can cause weight gain, hormone imbalances, and infertility. Researchers are exploring the possibility that GLP-1 medications may help with the management of PCOS to improve fertility and health outcomes.

Addiction and Mental Health Support

Early research suggests that GLP-1 drugs may help people with addictions, such as smoking or alcohol use. Scientists are also looking at whether these medications can improve mood and mental health conditions like depression.

GLP-1 medications are proving to be more than just weight loss drugs. Researchers continue to study how they can help in many areas of health.

Despite the promising benefits, know that GLP-1 medications are not a one-size-fits-all solution. They’re not for everyone and there can be side effects, some of which can be serious. If you’re considering a GLP-1 drug, check with your doctor to see if it’s a good choice for you.